学习经历

2006/09-2012/07    复旦大学，保送硕博连读，分子生物学专业

2011/03-2012/07    香港Hong Kong Baptist University，联合培养

2008/08-2011/03    美国Donald Danforth Plant Science Center，联合培养

2002/09-2006/07    复旦大学，本科，生物科学专业

工作经历

2019/10至今    中国农业大学农学院，教授

2017/11-2019/10    入选“唐氏 康奈尔-中国学者项目”，与康奈尔大学Edward Buckler院士团队合作开发人工智能技术

2016/01-2019/10    中国农科院生物技术研究所，副研究员

2012/07-2015/12    中国农科院生物技术研究所，助理研究员

智能设计育种。围绕玉米高产稳产育种目标，聚焦产量、生育期等关键农艺性状，综合利用深度学习、分子生物学、遗传学等技术从两方面开展人工智能辅助玉米遗传改良研究：1）人工智能指导下的基因编辑育种。针对控制重要农艺性状的关键基因，利用人工智能技术在转录调控区和编码区设计自然界不存在的优异等位变异，并通过基因编辑技术导入玉米，实现农艺性状的改良。2）基于人工智能的合成生物学。利用深度学习中的生成模型技术设计自然界不存在的具有特定生物学功能的元件，改良作物重要农艺性状。通过上述两部分研究，为基因编辑育种和合成生物学提供指导，提高生物育种效率。本实验室将从分子生物学实验和机器学习两方面为每一位研究生提供全方位的培养。欢迎对科研有梦想有追求的优秀学生报考本课题组研究生！

主持国家自然科学基金面上项目、国家自然科学基金青年项目、基础研究引导计划优青引导项目、协同创新项目等；参加国家重点研发计划“G2P:农作物基因资源阐析”项目、国家自然科学基金重点项目、国家重点研发计划“七大农作物育种”专项、隆平高科科企合作等项目。

(1) Sun G, Xia M, Li J, Ma W, Li Q, Xie J, Bai S, Fang S, Sun T, Feng X, Guo G, Niu Y, Hou J, Ye W, Ma J, Guo S, Wang H, Long Y, Zhang X, Zhang J, Zhou H, Li B, Liu J, Zou C, Wang H, Huang J, Galbraith DW, Song CP: The maize single-nucleus transcriptome comprehensively describes signaling networks governing movement and development of grass stomata. Plant Cell 2022.

(2) Huang Y, Huang W, Meng Z, Braz GT, Li Y, Wang K, Wang H, Lai J, Jiang J, Dong Z*, Jin W*: Megabase-scale presence-absence variation with Tripsacum origin was under selection during maize domestication and adaptation. Genome Biology 2021, 22(1):237.

(3) Song B#*, Buckler ES, Wang H, Wu Y, Rees E, Kellogg EA, Gates DJ, Khaipho-Burch M, Bradbury PJ, Ross-Ibarra J, Hufford MB, Romay MC: Conserved noncoding sequences provide insights into regulatory sequence and loss of gene expression in maize. Genome Research 2021.

(4) Wang H#*, Cimen E, Singh N, Buckler E: Deep learning for plant genomics and crop improvement. Current Opinion in Plant Biology 2020, 54:34-41.

(5) Liu J#, Li J, Wang H*, Yan J*: Application of deep learning in genomics. Science China Life Sciences 2020, 63(12):1860-1878.

(6) Wang B#, Lin Z#, Li X#, Zhao Y, Zhao B, Wu G, Ma X, Wang H, Xie Y, Li Q, Song G, Kong D, Zheng Z, Wei H, Shen R, Wu H, Chen C, Meng Z, Wang T, Li Y, Li X, Chen Y, Lai J, Hufford MB, Ross-Ibarra J, He H*, Wang H*: Genome-wide selection and genetic improvement during modern maize breeding. Nature Genetics 2020, 52(6):565-571.

(7) Xie S#, Luo H#, Huang Y, Wang Y, Ru W, Shi Y, Huang W, Wang H, Dong Z, Jin W*: A Missense Mutation in a Large Subunit of Ribonucleotide Reductase Confers Temperature-Gated Tassel Formation. Plant Physiology 2020, 184(4):1979-1997.

(8) Washburn JD#, Mejia-Guerra MK, Ramstein G, Kremling KA, Valluru R, Buckler ES*, Wang H#*: Evolutionarily informed deep learning methods for predicting relative transcript abundance from DNA sequence. PNAS 2019, 116(12):5542-5549.

(9) Wang H#*, Yan S#, Xin H, Huang W, Zhang H, Teng S, Yu YC, Fernie AR, Lu X, Li P, Li S, Zhang C, Ruan YL, Chen LQ*, Lang Z*: A Subsidiary Cell-Localized Glucose Transporter Promotes Stomatal Conductance and Photosynthesis. Plant Cell 2019, 31(6):1328-1343.

(10) Li S, Wang Z, Zhou Y, Li C, Wang G, Wang H, Zhang J, Liang G, Lang Z: Expression of cry2Ah1 and two domain II mutants in transgenic tobacco confers high resistance to susceptible and Cry1Ac-resistant cotton bollworm. Scientific Report 2018, 8(1):508.

(11) Xie Y#, Liu Y#, Wang H, Ma X, Wang B, Wu G, Wang H*: Phytochrome-interacting factors directly suppress MIR156 expression to enhance shade-avoidance syndrome in Arabidopsis. Nature Communication 2017, 8(1):348.

(12) Sun H, Zhou N, Wang H, Huang D, Lang Z: Processing and targeting of proteins derived from polyprotein with 2A and LP4/2A as peptide linkers in a maize expression system. PLoS One 2017, 12(3):e0174804.

(13) Liu Y#, Xie Y#, Wang H, Ma X, Yao W, Wang H: Light and Ethylene Coordinately Regulate the Phosphate Starvation Response through Transcriptional Regulation of PHOSPHATE STARVATION RESPONSE1. Plant Cell 2017, 29(9):2269-2284.

(14) Wang H#, Li S#, Teng S, Liang H, Xin H, Gao H, Huang D, Lang Z: Transcriptome profiling revealed novel transcriptional regulators in maize responses to Ostrinia furnacalis and jasmonic acid. PLoS One 2017, 12(5):e0177739.

(15) Wang H#, Wu G, Zhao B, Wang B, Lang Z, Zhang C, Wang H*: Regulatory modules controlling early shade avoidance response in maize seedlings. BMC Genomics 2016, 17:269.

(16) Pan YY, Chen R, Zhu L, Wang H, Huang DF, Lang ZH: Utilizing modified ubi1 introns to enhance exogenous gene expression in maize (Zea mays L.) and rice (Oryza sativa L.). Journal of Integrative Agriculture 2016, 15: 1716–1726

(17) Wang H#, Wang H: The miR156/SPL Module, a Regulatory Hub and Versatile Toolbox, Gears up Crops for Enhanced Agronomic Traits. Molecular Plant 2015, 8(5):677-688.

(18) Wang H#, Wang H: Multifaceted roles of FHY3 and FAR1 in light signaling and beyond. Trends in Plant Science 2015, 20(7):453-461.

(19) Wang H#, Wang H: Phytochrome signaling: time to tighten up the loose ends. Molecular Plant 2015, 8(4):540-551.

(20) Li S#, Wang H#, Li F, Chen Z, Li X, Zhu L, Wang G, Yu J, Huang D, Lang Z: The maize transcription factor EREB58 mediates the jasmonate-induced production of sesquiterpene volatiles. Plant Journal 2015, 84(2):296-308.

(21) Liu P, Zhang H, Wang H, Xia Y: Identification of redox-sensitive cysteines in the Arabidopsis proteome using OxiTRAQ, a quantitative redox proteomics method. Proteomics 2014, 14(6):750-762.

(22) Wang H#, Lu Y, Liu P, Wen W, Zhang J, Ge X, Xia Y: The ammonium/nitrate ratio is an input signal in the temperature-modulated, SNC1-mediated and EDS1-dependent autoimmunity of nudt6-2 nudt7. Plant Journal 2013, 73(2):262-275.

(23) Wang H#, Lu Y#, Jiang T, Berg H, Li C, Xia Y: The Arabidopsis U-box/ARM repeat E3 ligase AtPUB4 influences growth and degeneration of tapetal cells, and its mutation leads to conditional male sterility. Plant Journal 2013, 74(3):511-523.

(24) Wang H#, Wang S, Xia Y: Identification and verification of redox-sensitive proteins in Arabidopsis thaliana. Methods in Molecular Biology 2012, 876:83-94. (Book Chapter)

(25) Wang H#, Wang S, Lu Y, Alvarez S, Hicks LM, Ge X, Xia Y: Proteomic analysis of early-responsive redox-sensitive proteins in Arabidopsis. Journal of Proteome Research 2012, 11(1):412-424.

(26) Wang H#, Liang Q, Cao K, Ge X: Endogenous protein mono-ADP-ribosylation in Arabidopsis thaliana. Planta 2011, 233(6):1287-1292.

(27) Lu Y, Li C, Wang H, Chen H, Berg H, Xia Y: AtPPR2, an Arabidopsis pentatricopeptide repeat protein, binds to plastid 23S rRNA and plays an important role in the first mitotic division during gametogenesis and in cell proliferation during embryogenesis. Plant Journal 2011, 67(1):13-25.

(28) Wang X, Wang H, Li Y, Cao K, Ge X: A rice lipid transfer protein binds to plasma membrane proteinaceous sites. Molecular Biology Reports 2009, 36(4):745-750.

(29) Ge X, Wang H, Cao K: Transformation by T-DNA integration causes highly sterile phenotype independent of transgenes in Arabidopsis thaliana. Plant Cell Reports 2008, 27(8):1341-1348.