2005．9-2009.7 北京邮电大学 本科

2009．9-2014.7 清华大学  博士

2012.10-2013.10 美国加州大学洛杉矶分校 公派联培

2014．7-2016.6 北京大学  博士后

2016．6-2017.12 中国农业大学 讲师

2018 . 1至今  中国农业大学 副教授

17、18年春季学期本科生《植物基因组学》主讲

18年至今秋季学期本科生《作物生物信息学》主讲

21年至今秋季学期研究生《作物遗传育种专业英语》主讲

多倍体小麦复杂基因组解析与种质资源演化。

目前以小麦为研究对象，结合生物信息学、基因组学、人工智能等手段，围绕作物多组学大数据整合与挖掘、小麦基因组变异与演化规律解析、小麦种质资源构成与优异基因利用等问题，开展一系列原创性研究。

主要研究包括三个层面：（1）结合小麦多组学数据进行研究，回答多倍体小麦的驯化与育种选择、种质资源构成与演变、复杂基因调控网络等方面的科学问题；（2）针对小麦的复杂基因组解析和海量组学数据整合问题，结合算法和统计学模型，设计和开发新的生物信息学计算工具；（3）对小麦的基因组、转录组、表观组和泛基因组的海量数据进行整合分析，搭建数据可视化平台，旨在提高小麦多组学研究效率。

近年来，在西藏半野生小麦基因组组装与起源演化、作物泛基因组同源基因推断、基因组海量变异数据整合、小麦种质资源的基因组学网络解析、栽培四倍体-六倍体小麦起源与驯化等方向取得了一系列进展。已开发的原创算法和工具包括：BS-Seeker2（2013）、CGmapTools（2018）、SnpHub（2020）、GeneTribe（2020）、ggComp（2022）、IntroBlocker（2022）；已搭建的小麦基因组学数据库包括：Wheat-SnpHub-Portal（2020）、WheatUnion（2020）、Triticeae-GeneTribe/TGT（2020）、WheatCompDB（2022）。

（★ 第一作者/通信作者文章）

英文期刊论文：

★42. Zihao Wang, Wenxi Wang, Xiaoming Xie, Yongfa Wang, Zhengzhao Yang, Huiru Peng, Mingming Xin, Yingyin Yao, Zhaorong Hu, Jie Liu, Zhenqi Su, Chaojie Xie, Baoyun Li, Zhongfu Ni, Qixin Sun#, Weilong Guo#. (2022) Dispersed emergence and protracted domestication of polyploid wheat uncovered by mosaic ancestral haploblock inference, Nature Communications, accepted.

(# Joint Corresponding Author)

41. Qian Chen, Changfeng Yang, Zhaoheng Zhang, Zihao Wang, Yongming Chen, Vincenzo Rossi, Wei Chen, Mingming Xin, Zhenqi Su, Jinkun Du, Weilong Guo, Zhaorong Hu, Jie Liu, Huiru Peng, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2022) Unprocessed wheat γ-gliadin reduces gluten accumulation associated with the endoplasmic reticulum stress and elevated cell death, New Phytologist, https://doi.org/10.1111/nph.18316

★40. Zhengzhao Yang*, Zihao Wang*, Wenxi Wang*, Xiaoming Xie, Lingling Chai, Xiaobo Wang, Xibo Feng, Jinghui Li, Huiru Peng, Zhenqi Su, Mingshan You, Yingyin Yao, Mingming Xin, Zhaorong Hu, Jie Liu, Rongqi Liang, Zhongfu Ni, Qixin Sun, Weilong Guo#. (2022) ggComp enables dissection of germplasm resources and construction of a multiscale germplasm network in wheat, Plant Physiology, 188(4):1950-1965.

(# Corresponding Author; * Joint First Authors)

Software: ggComp: https://zack-young.github.io/ggComp/ 

Database: WheatCompDB: http://wheat.cau.edu.cn/WheatCompDB/

39. Lingling Chai, Mingming Xin, Chaoqun Dong, Zhaoyan Chen, Huijie Zhai, Junhong Zhuang, Xuejiao Cheng, Naijiao Wang, Jia Geng, Xiaobo Wang, Ruolin Bian, Yingyin Yao, Weilong Guo, Zhaorong Hu, Huiru Peng, Guihua Bai, Qixin Sun, Zhenqi Su, Jie Liu, Zhongfu Ni. (2022) A natural variation in Ribonuclease H-like gene underlies Rht8 to confer “Green Revolution” trait in wheat, Molecular Plant, 15(3):377-380.

38. Zhaoyan Chen, Wensheng Ke, Fei He, Lingling Chai, Xuejiao Cheng, Huanwen Xu, Xiaobo Wang, Dejie Du, Yidi Zhao, Xiyong Chen, Jiewen Xing, Mingming Xin, Weilong Guo, Zhaorong Hu, Zhenqi Su, Jie Liu, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni. (2022) A single nucleotide deletion in the third exon of FT-D1 increases the spikelet number and delays heading date in wheat (Triticum aestivum L.), Plant Biotechnology Journal, 20(5):920-933.

37. Shengwei Ma, Meng Wang, Jianhui Wu, Weilong Guo, Yongming Chen, Guangwei Li, Yanpeng Wang, Weiming Shi, Guangmin Xia, Daolin Fu, Zhensheng Kang, Fei Ni. (2021) WheatOmics: A platform combining multiple omics data to accelerate functional genomics studies in wheat, Molecular Plant, 14(12):1965-1968.

Database: WheatOmics: http://wheatomics.sdau.edu.cn/ 

36. Zhiyu Feng, Long Song, Wanjun Song, Zhongqi Qi, Jun Yuan, Run Li, Haiming Han, Huifang Wang, Zhaoyan Chen, Weilong Guo, Mingming Xin, Jie Liu, Zhaorong Hu, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni, Jiewen Xing. (2021) The decreased expression of GW2 homologous genes contributed to the increased grain width and thousand‑grain weight in wheat-Dasypyrum villosum 6VS·6DL translocation lines, Theoretical and Applied Genetics, 134(12):3873-3894.

35. Xiang Gao, Weipeng Mo, Junpeng Shi, Ning Song, Pei Liang, Jian Chen, Yiting Shi, Weilong Guo, Xinchen Li, Xiaohong Yang, Beibei Xin, Haiming Zhao, Weibin Song, Jinsheng Lai. (2021) HITAC-seq enables high-throughput cost-effective sequencing of plasmids and DNA fragments with identity-tracked, Journal of Genetics and Genomics, 48(8):671-680.

34. Qiang Zhang, Wenxin Wei, Xiangxi Zuansun, Shengnan Zhang, Chen Wang, Nannan Liu, Lina Qiu, Weidong Wang, Weilong Guo, Jun Ma, Huiru Peng, Zhaorong Hu, Qixin Sun, Chaojie Xie. (2021) Fine Mapping of the Leaf Rust Resistance Gene Lr65 in Spelt Wheat ‘Altgold’, Frontiers in Plant Science, 12:666921.

33. Lina Qiu, Nannan Liu, Huifang Wang, Xiaohan Shi, Feng Li, Qiang Zhang, Weidong Wang, Weilong Guo, Zhaorong Hu, Hongjie Li, Jun Ma, Qixin Sun, Chaojie Xie. (2021) Fine mapping of a powdery mildew resistance gene MlIW39 derived from wild emmer wheat (Triticum turgidum ssp. dicoccoides), Theoretical and Applied Genetics, 134(8):2469-2479.

32. Jing Liu, Zhaoyan Chen, Zhihui Wang, Zhaoheng Zhang, Xiaoming Xie, Zihao Wang, Lingling Chai, Long Song, Xuejiao Cheng, Man Feng, Xiaobo Wang, Yanhong Liu, Zhaorong Hu, Jiewen Xing, Zhenqi Su, Huiru Peng, Mingming Xin, Yingyin Yao, Weilong Guo, Qixin Sun, Jie Liu, Zhongfu Ni. (2021) Ectopic expression of VRT-A2 underlies the origin of Triticum polonicum and Triticum petropavlovskyi with long outer glumes and grains, Molecular Plant, 14(9):1472-1488.

31. Dejie Du, Dongxue Zhang, Jun Yuan, Man Feng, Zhaoju Li, Zihao Wang, Zhaoheng Zhang, Xiongtao Li, Wensheng Ke, Renhan Li, Zhaoyan Chen, Lingling Chai, Zhaorong Hu, Weilong Guo, Jiewen Xing, Zhenqi Su, Huiru Peng, Mingming Xin, Yingyin Yao, Qixin Sun, Jie Liu, Zhongfu Ni. (2021) FRIZZY PANICLE defines a regulatory hub for simultaneously controlling spikelet formation and awn elongation in bread wheat, New Phytologist, 231(2):814-833.

30. Linghong Li, Lingling Chai, Huanwen Xu, Huijie Zhai, Tianya Wang, Mingyi Zhang, Mingshan You, Huiru Peng, Yingyin Yao, Zhaorong Hu, Mingming Xin, Weilong Guo, Qixin Sun, Xiyong Chen, Zhongfu Ni. (2021) Phenotypic characterization of the glossy1 mutant and fine mapping of GLOSSY1 in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics. 134(3):835-847.

29. Yujiao Gao, Kexin An, Weiwei Guo, Yongming Chen, Ruijie Zhang, Xue Zhang, Siyuan Chang, Vincenzo Rossi, Fangming Jin, Xinyou Cao, Mingming Xin, Huiru Peng, Zhaorong Hu, Weilong Guo, Jinkun Du, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2021) The endosperm-specific transcription factor TaNAC019 regulates glutenin and starch accumulation and its elite allele improves wheat grain quality, The Plant Cell. 33(3):603-622.

28. Kuohai Yu, Man Feng, Guanghui Yang, Lv Sun, Zhen Qin, Jie Cao, Jingjing Wen, Haoran Li, Yan Zhou, Xiangping Chen, Huiru Peng, Yingyin Yao, Zhaorong Hu, Weilong Guo, Qixin Sun, Zhongfu Ni, Keith Adams, Mingming Xin. (2020) Changes in Alternative Splicing in Response to Domestication and Polyploidization in Wheat, Plant Physiology, 184(4):1955-1968.

★27. Yongming Chen, Wanjun Song, Xiaoming Xie, Zihao Wang, Panfeng Guan, Huiru Peng, Yuannian Jiao, Zhongfu Ni, Qixin Sun, Weilong Guo#. (2020) A Collinearity-incorporating Homology Inference Strategy for Connecting Emerging Assemblies in Triticeae Tribe as a Pilot Practice in the Plant Pangenomic Era, Molecular Plant, 13(12):1694-1708.

(# Corresponding Author)

Software: GeneTribe: https://chenym1.github.io/genetribe/ 

Database: Triticeae-GeneTribe (TGT): http://wheat.cau.edu.cn/TGT/ 

★26. Weilong Guo*, Mingming Xin *, Zihao Wang *, Yingyin Yao, Zhaorong Hu, Wanjun Song, Kuohai Yu, Yongming Chen, Xiaobo Wang, Panfeng Guan, Rudi Appels, Huiru Peng#, Zhongfu Ni#, Qixin Sun#. (2020) Origin and adaptation to high altitude of Tibetan semi-wild wheat, Nature Communications, 11:5085.

(# Corresponding Authors; * Joint First Authors)

Zang817_Genome: http://wheat.cau.edu.cn/Zang1817_genome/ 

SnpHub-NC20: http://wheat.cau.edu.cn/Wheat_SnpHub_Portal/balancer/?appname=snphub_NC20 

★25. Wenxi Wang*, Zihao Wang*, Xintong Li, Zhongfu Ni, Zhaorong Hu, Mingming Xin, Huiru Peng, Yingyin Yao, Qixin Sun, Weilong Guo#. (2020) SnpHub: an easy-to-set-up web server framework for exploring large-scale genomic variation data in the post-genomic era with applications in wheat, GigaScience, 9(6):giaa060.

(# corresponding author; * Joint First Authors)

Software: SnpHub, http://guoweilong.github.io/SnpHub/

Database: Wheat-SnpHub-Portal, http://wheat.cau.edu.cn/Wheat_SnpHub_Portal/

24. Lina Qiu, Huifang Wang, Yinghui Li, Weidong Wang, Yujia Liu, Junyi Mu, Miaomiao Geng, Weilong Guo, Zhaorong Hu, Jun Ma, Qixin Sun, Chaojie Xie. (2020) Fine Mapping of the Wheat Leaf Rust Resistance Gene LrLC10 (Lr13) and Validation of Its Co-segregation Markers, Frontiers in Plant Science, 11:470.

23. Feng Huang, Zhaoyan Chen, Dejie Du, Panfeng Guan, Lingling Chai, Weilong Guo, Zhaorong Hu, Mingming Xin, Huiru Peng, Yingyin Yao, Zhongfu Ni. (2020) Genome-wide linkage mapping of QTL for root hair length in a Chinese common wheat population, The Crop Journal, 8(6):1049-1056.

22. Jinghui Li, Shaozhe Wen, Chaofeng Fan, Minghu Zhang, Shuai Tian, Wenjing Kang, Wenxin Zhao, Chan Bi, Qiuyan Wang, Shuang Lu, Weilong Guo, Zhongfu Ni, Chaojie Xie, Qixin Sun, Mingshan You. (2020) Characterization of a major quantitative trait locus on the short arm of chromosome 4B for spike number per unit area in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 133(7):2259-2269.

21. Xuejiao Cheng, Mingming Xin, Ruibin Xu, Zhaoyan Chen, Wenlong Cai, Lingling Chai, Huanwen Xu, Lin Jia, Zhiyu Feng, Zihao Wang, Huiru Peng, Yingyin Yao, Zhaorong Hu, Weilong Guo , Zhongfu Ni, Qixin Sun. (2020) A Single Amino Acid Substitution in STKc_GSK3 Kinase Conferring Semispherical Grains and Its Implications for the Origin of Triticum sphaerococcum , The Plant Cell, 133(6):1825–1838.

20. Zhaoyan Chen, Xuejiao Cheng, Lingling Chai, Zihao Wang, Dejie Du, Zhihui Wang, Ruolin Bian, Aiju Zhao, Mingming Xin, Weilong Guo, Zhaorong Hu, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni . (2020) Pleiotropic QTL influencing spikelet number and heading date in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 133(6):1825–1838.

19. Linghong Li, Zhongqi Qi, Lingling Chai, Zhaoyan Chen, Tianya Wang, Mingyi Zhang, Mingshan You, Huiru Peng, Yingyin Yao, Zhaorong Hu, Mingming Xin, Weilong Guo, Qixin Sun, Zhongfu Ni . (2020) The semidominant mutation w5 impairs epicuticular wax deposition in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 133(4):1213–1225.

18. Zhaoyan Chen, Xuejiao Cheng, Lingling Chai, Zhihui Wang, Ruolin Bian, Jiang Li, Aiju Zhao, Mingming Xin, Weilong Guo, Zhaorong Hu, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni. (2019) Dissection of genetic factors underlying grain size and fine mapping of QTgw.cau‐7D in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics, pp 1–14.

17. Kaiye Liu, Jie Cao, Kuohai Yu, Xinye Liu, Yujiao Gao, Qian Chen, Wenjia Zhang, Huiru Peng, Jinkun Du, Mingming Xin, Zhaorong Hu, Weilong Guo, Vincenzo Rossi, Zhongfu Ni, Qixin Sun, and Yingyin Yao. (2019) Wheat TaSPL8 Modulates Leaf Angle Through Auxin and Brassinosteroid Signaling, Plant Physiology, pp.00248.2019.

16. Ning Zhang, Jing Xu, Xinye Liu, Wenxing Liang, Mingming Xin, Jinkun Du, Zhaorong Hu, Huiru Peng, Weilong Guo, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2019) Identification of HSP90C as a substrate of E3 ligase TaSAP5 through ubiquitylome profiling, Plant Science, 287, 110170.

15. Panfeng Guan, Na Di, Qing Mu, Xueyi Shen, Yongfa Wang, Xiaobo Wang, Kuohai Yu, Wanjun Song, Yongming Chen, Mingming Xin, Zhaorong Hu, Weilong Guo, Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru Peng. (2019) Use of near-isogenic lines to precisely map and validate a major QTL for grain weight on chromosome 4AL in bread wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 132, 2367–2379.

14. Peng Wu, Yan Gao, Weilong Guo, Ping Zhu. (2019) Using Local Alignment to Enhance Single Cell Bisulfite Sequencing Data Efficiency, Bioinformatics, 35(18):3273–3278.

Software: scBS-map, https://github.com/wupengomics/scBS-map 

13. Haichuan Zhu, Liuzhen Zhang, Yilin Wu, Bingjie Dong, Weilong Guo, Mei Wang, Lu Yang, Xiaoying Fan, Yuliang Tang, Ningshu Liu, Xiaoguang Lei, Hong Wu. (2018) T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1, eLife, 7:e38314.

12. Lingling Chai, Zhaoyan Chen, Ruolin Bian, Huijie Zhai, Xuejiao Cheng, Huiru Peng, Yingyin Yao, Zhaorong Hu, Mingming Xin, Weilong Guo, Qixin Sun, Aiju Zhao, Zhongfu Ni. (2018) Dissection of two quantitative trait loci with pleiotropic effects on plant height and spike length linked in coupling phase on the short arm of chromosome 2D of common wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 131(12):2621–2637.

11. Yongkang Zou, Zhi Qi, Weilong Guo, Liuzhen Zhang, Marcus Ruscetti, Tanu Shenoy, Ningshu Liu, Hong Wu. (2018) Cotargeting the Cell-Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kα/β/δ Inhibitor BAY1082439, Molecular Cancer Therapeutics, 17(10):2091-2099.

★10. Weilong Guo*#, Ping Zhu*, Matteo Pellegrini, Michael Zhang, Xiangfeng Wang, Zhongfu Ni. (2018) CGmapTools improves the precision of heterozygous SNV calls and supports allele-specific methylation detection and visualization in bisulfite-sequencing data, Bioinformatics, 34:381–387.

(# corresponding author; * Joint First Authors)

Software: CGmapTools, https://cgmaptools.github.io 

09. Shenoy TR, Boysen G, Wang MY, Xu QZ, Guo W, Koh FM, Wang C, Zhang LZ, Wang Y, Gil V, et al., Aziz S, Christova R, Rodrigues DN, Crespo M, Rescigno P, Tunariu N, Riisnaes R, Zafeiriou Z, Flohr P, Yuan W, Knight E, Swain A, Ramalho-Santos M, Xu DY, de Bono J, Wu H. (2017) CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair, Annals of Oncology, April.

★08. Weilong Guo#, Michael Zhang, Hong Wu#. (2016) Mammalian non-CG methylations are conserved and cell-type specific and may have been involved in the evolution of transposon elements, Scientific Reports, 6:32207.

(# corresponding authors)

07. Qingying Meng, Zhe Ying, Emily Noble, Yuqi Zhao, Rahul Agrawal, Andrew Mikhail, Yumei Zhuang, Ethika Tyagi, Qing Zhang, Jae-Hyung Lee, Marco Morselli, Luz Orozco, Weilong Guo, Tina M. Kilts, Jun Zhu, Bin Zhang, Matteo Pellegrini, Xinshu Xiao, Marian F. Young, Fernando Gomez-Pinilla, Xia Yang. (2016) Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders, EBioMedicine, May(7):157-66.

06. Marcus Ruscetti, Eman L. Dadashian, Weilong Guo, Bill Quach, David J. Mulholland, Juw W. Park, Linh M. Tran, Naoko Kobayashi, Daniella Bianchi-Frias, Peter S. Nelson, Yi Xing, and Hong Wu. (2015) HDAC Inhibition Impedes HMGA2-controlled Epithelial-Mesenchymal Plasticity and Suppresses Metastatic, Castration-Resistant Prostate Cancer, Oncogene, (August),1-15.

05. Luz D Orozco, Marco Morselli, Liudmilla Rubbi, Weilong Guo, James Go, Huwenbo Shi, David Lopez, Nicholas A Furlotte, Brian J Bennett, Charles R Farber, Anatole Ghazalpour, Michael Q Zhang, Renata Bahous, Rima Rozen, Aldons J Lusis, Matteo Pellegrini. (2015) Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice, Cell Metabolism, 21(6):905-917.

04. Yun Li, Jason A. Chen, Renee L. Sears, Fuying Gao, Eric D. Klein, Anna Karydas, Michael D. Geschwind, Howard J. Rosen, Adam L. Boxer, Weilong Guo, Matteo Pellegrini, Steve Horvath, Bruce L. Miller, Daniel H. Geschwind, Giovanni Coppol. (2014) An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy, PLoS Genetics, 10(3).

★03. Weilong Guo, Wen-Yu Chung, Minping Qian, Matteo Pellegrini, Michael Q. Zhang. (2014) Characterizing the strand-specific distribution of non-CpG methylation in human pluripotent cells, Nucleic Acids Research, 42(5): 3009-3016.

★02. Weilong Guo, Petko Fiziev, Weihong Yan, Shawn Cokus, Xueguang Sun, Michael Q. Zhang, Pao-Yang Chen, Matteo Pellegrini. (2013) BS-Seeker2: a versatile aligning pipeline for bisulfite sequencing data. BMC Genomics, 14(1), 774.

Software: BS-Seeker2, http://pellegrini.mcdb.ucla.edu/BS_Seeker2/ 

01. Ruijuan Li, Weilong Guo, Jin Gu, Michael Q. Zhang, Xiaowo Wang. (2012) Chromatin state and microRNA determine different gene expression dynamics responsive to TNF stimulation, Genomics, 100(5):297-302.

中文期刊论文：

★02. 杨正钊,王梓豪,胡兆荣,辛明明,姚颖垠,彭惠茹,尤明山,宿振起#,郭伟龙#.(2020). 小麦主栽品种济麦22与良星99的基因组序列多态性比较分析. 作物学报 46(12):1870-1883.

（#共同通信作者）

01. 寇小霞,张丽媛,赵月,田雪军,郭伟龙,辛明明,彭惠茹.(2018). 拟南芥翻译起始因子eIF5B-1调控种子萌发的分子机制. 中国农业大学学报23(01): 12-18.